Pediatrics · Advanced

Mineral and bone disorders in children, a pediatric nephrologist's perspective

A pediatric nephrologist's view of mineral and bone disorders: learn to detect hidden pathology of phosphorus-calcium metabolism in time and correct it competently.

24academic hours

Advancedlevel

Distance learningmode of study

Course curriculum

Physiology of mineral-bone metabolism in children
Physiology of calcium-phosphorus metabolism
Calcium content in foods
Calcium storage and excretion
Stages of phosphorus metabolism and intake
Forms of vitamin D3
Vitamin D3 (Cholecalciferol)
Vitamin D metabolism
Functions of parathyroid hormone
Calcitonin
Pathology of calcium metabolism
Calcium metabolism disorder
Acute and chronic hypocalcemia
Phosphorus metabolism disorder
Hypophosphatemia. Clinical presentation, cause
Vitamin D deficiency and excess
Hyperparathyroidism. Pseudohyperparathyroidism. Hypoparathyroidism
Calcitonin disorder
Pathology of phosphorus metabolism
Laboratory research methods
Total blood calcium
Hypercalcemia
Phosphorus (inorganic)
Hyper/hypophosphatemia, Alkaline phosphatase, its functions. Causes of elevation and reduction
Intact parathyroid hormone. Causes of elevation and reduction
Calcitonin
Vitamin D and its fractions. Vitamins D2 and D3 in blood serum
Hypercalciuria. Sulkowitch test. Hyper/hypophosphaturia
Calcium-phosphorus product. Genetic testing
Instrumental and other methods of studying calcium-phosphorus metabolism. Ultrasound. CT and MRI – densitometry. Parathyroid gland scintigraphy
Bone scintigraphy. Types of osteoscintigraphy
Pathology of vitamin D metabolism. Rickets
Rickets. Etiology, classification
Calcipenic rickets. Phosphopenic rickets
Rickets without pronounced changes in blood calcium and phosphorus concentrations
Degrees and periods of rickets development
Acute, subacute and recurrent course of rickets
Clinical presentation and diagnosis of rickets
Antenatal and postnatal prophylaxis
Non-pharmacological treatment. Pharmacological treatment
Pathology of vitamin D metabolism. Rickets-like diseases
Phosphate diabetes. Etiology. Pathogenesis. Classification
Autosomal dominant hypophosphatemic rickets
Clinical presentation, diagnosis, treatment of phosphate diabetes. Prognosis and prevention
Osteogenesis imperfecta. Etiology, pathogenesis, classification
Dentinogenesis imperfecta. Intrauterine and late forms. Diagnosis, treatment, prevention
Achondroplasia (Chondrodysplasia). Etiology, pathogenesis, classification. Diagnosis, treatment, prevention. Infigratinib. Vosoritide
Blount's disease
Congenital hypothyroidism
Hereditary hyperphosphatasia
Hereditary hypophosphatasia. Perinatal, childhood, adult form of HP
Laboratory diagnostics
Asfotase alfa. Symptomatic treatment
Vitamin D-dependent rickets type 2
Renal tubular acidosis
Dent disease ICD N39.8. HDR syndrome (Barakat syndrome) Q87.8
Primary hyperparathyroidism
Secondary hyperparathyroidism
Primary hypoparathyroidism
Secondary hypoparathyroidism
Pseudohypoparathyroidism
Early variants of diseases with impaired phosphorus-calcium metabolism. Paget's disease
Hereditary hypocalciuric hypercalcemia
Severe neonatal hyperparathyroidism. Wilms syndrome
Elfin face
Adynamic bone disease
Diabetes mellitus and P-Ca metabolism. GCS therapy
Granulomatous diseases
Other pathophysiological processes in mineral and bone metabolism
Drug therapy of calcium-phosphorus metabolism disorders
Calcium preparations. Pharmacokinetics and pharmacodynamics. Dosing
Calcium chloride
Calcium glycerophosphate
Calcium carbonate, acetate, citrate
Calcium preparations in combination with vitamin D. Indications, side effects
Rocaltrol (calcitriol). Pharmacokinetics and pharmacodynamics. Dosing. Indications, side effects
Paricalcitol (active metabolite of vitamin D — a selective activator of receptors in the parathyroid glands)
Maxacalcitol (22-oxacalcitriol). Miacalcic. Etelcalcetide
Cinacalcet (Mimpara). Bisphosphonates
Phosphate binders. Classification
Romosozumab (Evenity)
Burosumab (Crysvita)
Drug-induced hypercalcemia. Drug-induced hyperphosphatemia. Drug-induced hypophosphatemia
Clinical cases
Analysis of clinical cases

Mineral and bone disorders in children remain asymptomatic for a long time, and the first signal is already skeletal deformities and growth retardation. The course is led by a practising paediatric nephrologist and helps you read biochemistry and bone-turnover markers as a single picture rather than a set of disconnected tests.

You will examine the management tactics in CKD and other conditions, and after the training you will confidently build a correction and monitoring plan, relying on evidence-based approaches and real clinical scenarios.

Khoroshev Sergey Anatolyevich

Pediatrician, pediatric nephrologist

Pediatrician and pediatric nephrologist with eight years of experience, whose training covers both general pediatrics and the narrow specialization of nephrology. Useful for learners interested in the diagnosis and management of kidney diseases in children.

Pediatrician, pediatric nephrologist. Work experience — 8 years.

Education

Faculty of Pediatrics, Ural State Medical University
Residency in pediatrics at Regional Children's Clinical Hospital No. 1
Primary professional retraining in the specialty «Nephrology», Russian Medical Academy of Postgraduate Education

Open Instructor Page →

These courses may interest you

Advanced

Pediatrics36 ч

Diagnosis and management of ENT diseases in children under one year of age

ENT pathology in infants in the first year of life: how to recognize alarming symptoms in time and choose the right approach in the most vulnerable patient.

Kolesnikova A.V. Learn More

Advanced

Pediatrics18 ч

Features of pediatric gastroenterology

Pediatric gastroenterology with its nuances: how to recognize that a real problem lies behind "frequent abdominal pain".

Moskvina M.V. Learn More

Advanced

Pediatrics18 ч

Inflammatory diseases of the ENT organs in children

Inflammatory ENT diseases in children: rational diagnosis and treatment without excessive antibiotic therapy and complications.

Sitnikova I.S. Learn More