Diagnosis and treatment of dyslipidemias according to Russian and European guidelines

Course curriculum

• Review of the new Russian clinical guidelines "Lipid metabolism disorders"
• Federal clinical guidelines
• Risk categories and target lipid levels
• Algorithms of drug therapy
• Summary data on the effects of lipid-lowering drugs
• Diagnosis of dyslipidemia
• Classification
• Screening
• Methods of assessing low-density lipoproteins
• Cardiovascular risk assessment
• Lipoprotein (a)
• The SCORE, SCORE-2, SCORE2-OP scales
• Imaging
• Goals and objectives for the prevention of cardiovascular diseases
• Strategy for elevated low-density lipoproteins
• The effect of lifestyle changes on lipid levels
• Will dietary supplements help in primary prevention?
• Dietary supplements and functional foods for the correction of dyslipidemias
• Application of statins for the treatment of dyslipidemia
• Mechanism of action of statins
• Classification of statins
• Main and additional effects of statins
• The physician's course of action
• Differences between statins, pharmacokinetics, drug interactions
• The JUPITER and HOPE-3 studies
• The effect of statin therapy on the risk of stroke and the risk of ischemic complications
• Statin intolerance and the main adverse events with their use
• Prevalence of statin intolerance
• Side effects
• Factors that increase the risk of adverse events
• Statins and liver function
• Positive effects of statins in liver diseases
• What to do in case of elevated liver enzymes?
• Risk of diabetes mellitus, hemorrhagic stroke
• Drug interactions
• Other lipid-lowering agents
• Ezetimibe
• Algorithm for selecting lipid-lowering therapy
• Proprotein convertase subtilisin/kexin type 9 inhibitors
• Fibrates
• Omega-3
• Familial hypercholesterolemia (FH)
• Definition, prevalence
• Types of FH
• Mutations in FH
• Secondary hypercholesterolemias
• Diagnostic criteria for FH according to the Dutch Lipid Clinic Network
• Simon Broome criteria
• Complaints and history, physical examination, laboratory tests, molecular genetic testing
• Cascade screening
• Treatment
• Clinical case of selecting therapy for dyslipidemia