Safety and Contraindications of CEUS: Adverse Reactions of SonoVue
Regarding the requested topic — the safety profile and contraindications of contrast-enhanced ultrasound (CEUS) using SonoVue — the provided source fragments do not contain specific factual data: frequency of adverse reactions, their classification, list of absolute and relative contraindications, as well as specific EFSUMB safety recommendations. [clarify]
What is Confirmed by the Fragments
The fragments contain bibliographic references to studies indirectly addressing CEUS safety issues in certain clinical scenarios, but numerical and qualitative data on adverse reactions are absent in the text of the fragments.
| Clinical Scenario | Mentioned Source (from fragments) | Safety Data |
|---|---|---|
| Voiding urosonography in children (second-generation contrast) | Papadopoulou F, Ntoulia A, et al. Pediatr Radiol 2014; prospective safety assessment of contrast in 1,010 children | Numerical indicators are not provided in the fragment [clarify] |
| Assessment of focal liver lesions in pregnant women | Schwarze V, et al. Ultraschall Med 2020; 41:29-35 (assessment of diagnostic efficacy and safety of CEUS) | Specific data on reactions are absent in the fragment [clarify] |
| Extrahepatic applications of CEUS | Sidhu PS, Cantisani V, Dietrich CF, et al. EFSUMB Guidelines Non-Hepatic Applications: Update 2017 | The safety section is not quoted in the fragments [clarify] |
Limitations of This Material
According to the requirements for medical publications, any information on the frequency of anaphylactoid and other adverse reactions of SonoVue, as well as contraindications to the introduction of contrast, cannot be provided without direct citation of the primary source. Such information is absent in the provided block of fragments.
A comprehensive article requires access to the safety sections of current EFSUMB guidelines on CEUS and the official instructions for use of SonoVue (Lumason package insert is mentioned in one of the fragments, but without substantive data). [clarify]
Frequently asked questions
What is the frequency of adverse reactions of SonoVue according to the fragments?
The provided fragments do not contain numerical data on the frequency of adverse reactions of SonoVue. [clarify]
What contraindications for CEUS are listed in the sources?
The list of contraindications is absent in the provided fragments. [clarify]
Can CEUS be used in pregnant women according to the fragments?
The fragments reference a study by Schwarze V, et al. (Ultraschall Med 2020) on the assessment of focal liver lesions in pregnant women, but specific safety data are not quoted. [clarify]
Has the safety of the contrast been studied in children?
Yes, a prospective study on the safety of second-generation contrast in 1,010 children during voiding urosonography is mentioned (Papadopoulou F, et al., Pediatr Radiol 2014), but the results are not disclosed in the fragment. [clarify]